Uses of 1-Cyanoacetyl-4-Phenyl-3-Thiosemicarbazide in the Synthesis of Antimicrobial and Antifungal Heterocyclic Compounds

The thiosemicarbazide synthesized from the reaction of cyanoacetylhydrazine phenylisothiocyanate reacted with acetoacetanilide gave the 2-pyridinone derivative 4. The reaction of the latter product with 1,3-dicarbonyl and α-halocarbonyl compounds gave the benzo[c]pyridine derivatives 6a,b and the thiazole derivatives 9a,b, respectively. The reaction with phenylisothiocyanate and elemental sulfur gave the thiazole derivative 14. The latter compound reacted with α-halocarbonyl compounds to give the thiazole products 16a-c. The antimicrobial and antifungal evaluations of the newly synthesized products showed that some compounds have high activity.