H1N1 Vaccine May Cause Hepatic Dysfunction

Aim: In this case, we reported an unusual side effect which may be related to adjuvant H1N1 vaccine.

Case Report: A sixty-three year-old man was admitted to our hospital with fever, nausea, vomiting and fatigue 15 days after his immunization against H1N1 virus. Laboratory findings were, aspartate aminotransferase (AST):620 U/L, alanine aminotransferase (ALT): 561 U/L, alkaline phosphatase (ALP):152 U/L, gamma-glutamyl transferase (GGT): 482 U/L. His clinical symptoms resolved within two days. His elevated liver function tests reduced gradually and completely normalized on day 6 of his hospitalization.

Discussion and Conclusion: H1N1 vaccination may cause increases in liver enzymes and it should be considered in differential diagnosis of abnormal liver function tests.